Carboxylesterase nucleic acid molecules, proteins and uses thereof
AssigneeHeska Corporation
InventorsGary M. Silver, Nancy Wisnewski, Kevin S. Brandt
Life of this patent
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Abstract
The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
Claims12
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a nucleic acid molecule that encodes a protein selected from the group consisting of SEQ ID NO:68 and proteins that are at least 95% identical to SEQ ID NO:68, wherein said protein exhibits carboxylesterase activity;
- and (b) an isolated nucleic acid molecule fully complementary to a nucleic acid molecule of (a).
An isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:68 and an amino acid sequence 95% identical to SEQ ID NO:68, wherein said isolated protein has carboxylesterase activity.
Dependencies are inferred from the claim text.