DNA encoding ACPL
AssigneeImmunex Corporation
InventorsJohn E. Sims, Teresa L. Born
Life of this patent
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Abstract
The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
Claims12
An isolated nucleic acid molecule comprising a DNA sequence selected from the group consisting of:
- a) the coding region of SEQ ID NO:6;
- and
- b) DNA that hybridizes under moderately stringent conditions to the DNA of a), wherein the moderately stringent conditions include 50% formamide an 6×SSC, at 42° C. with washing conditions of 60° C., 0.5×SSC, 0.1% SDS, and, wherein the DNA encodes a polypeptide that is a cofactor in IL-18 binding.
An isolated nucleic acid molecule encoding a polypeptide, wherein said polypeptide comprises an amino acid sequence that is at least 90% identical to SEQ ID NO:7 and the polypeptide is a cofactor in IL-18 binding.
An isolated nucleic acid molecule comprising a nucleic acid that encodes a polypeptide comprising SEQ ID NO:7.
An isolated nucleic acid encoding a soluble polypeptide, wherein said soluble polypeptide comprises an amino acid sequence that is at least 90% identical to amino acids x1 to 356 of SEQ ID NO:7, wherein x1 is amino acid 1 or 15, and wherein the soluble polypeptide is a cofactor in IL-18 binding.
An isolated nucleic acid encoding a polypeptide comprising amino acids x1 to 356 of SEQ ID NO:7, wherein x1 is amino acid 1 or 15.
An isolated nucleic acid encoding a polypeptide comprising SEQ ID NO:7.
An isolated nucleic acid encoding a polypeptide comprising amino acids x1 to 356 of SEQ ID NO:7, wherein x1 is amino acid 1 or 15.
Dependencies are inferred from the claim text.