Pablo, a polypeptide that interacts with Bcl-xL, and uses related thereto
AssigneeWyeth
InventorsRobert Mark, Kathleen H. Young, Andrew T. Wood
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Abstract
The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.
Claims8
An antibody which binds a Pablo polypeptide comprising an amino acid sequence of SEQ ID NO:2, wherein the antibody inhibits a Pablo/Bcl-xL binding interaction.
An antibody which binds a Pablo polypeptide fragment comprising amino acid 419 through amino acid 559 of SEQ ID NO:2.
An antibody which binds a Pablo polypeptide fragment consisting of amino acid 419 through amino acid 559 of SEQ ID NO:2.
An antibody which binds a Pablo polypeptide fragment consisting of amino acid 429 through amino acid 559 of SEQ ID NO:2.
An antibody which binds a Pablo Bcl-xL polypeptide dimer.
Dependencies are inferred from the claim text.