Assay for propensity for canine malignant hyperthermia
AssigneeWisconsin Alumni Research Foundation
InventorsKirk J. Hogan, David B. Brunson, Monica C. Roberts, James R. Mickelson
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Abstract
A method of determining whether a canine is susceptible to canine malignant hyperthermia is disclosed. In one embodiment, this method comprises the step of obtaining a nucleic acid sample from a canine and examining the DNA sample for the presence or absence of a T1640C mutation, wherein the presence of the mutation indicates that the canine is susceptible to canine malignant hyperthermia.
Claims6
A method of determining whether a canine is susceptible to canine maliqnant hyperthermia, comprising the step of obtaining a nucleic acid sample from a canine and examining the sample for the presence.
A kit for determining whether a canine is susceptible to canine malignant hyperthermia comprising:
- (a) a set of primers useful for amplifying at least a portion of the canine genome, wherein the amplified portion oomprises a nucleic acid encoding SEQ ID NO:1;
- and
- (b) a restriction endonuclease capable of differential cleavage in the presence or absence of a nucleic acid encoding SEQ ID NO:1.
Dependencies are inferred from the claim text.