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US 6,664,058 B2Granted
Base analogues
AssigneesAmersham Biosciences UK Limited, Medical Research Council Laboratories of Molecular Biology
InventorsShiv Kumar, Satyam Nampalli, Constantin Neagu, Mark McDougall, David Loakes, Dan Brown
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Abstract
The present invention describes novel compounds of the formula Wherein Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue, Y=O, S, NR10, where R10 is H, alkyl alkenyl, alkynyl, X is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl or a combination thereof or, preferably, a reporter group. The novel compounds are suitable for incorporation in oligonucleotides and polynucleotides.
Claims12
A compound comprising
- wherein:
- Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue;
- X is H, alkyl, alkenyl, alkynyl, aryl, hetero-aryl or a combination thereof or a reporter;
- and
- Y=O, S, NR where R is H, alkyl, alkenyl, or alkynyl.
2 more elements
Dependencies are inferred from the claim text.