Pancreatic cancer genes
AssigneeChiron Corporation
InventorGuilia C. Kennedy
Life of this patent
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Abstract
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
Claims7
A method of diagnosing dysplasia and cancer comprising the steps of:
- determining the amount of mRNA molecules in a sample tissue of a human suspected of being dysplastic or cancerous and in a human tissue which is normal, wherein said mRNA molecules are complementary to an isolated subgenomic polynucleotide comprising at least twenty contiguous nucleotides of th polynucleotide sequence of SEQ ID NO:2 or its complement;
- and
- comparing the determined amounts of mRNA molecules;
- wherein a sample human tissue which contains more of the mRNA molecules than the normal tissue is identified as being dysplastic or cancerous.
Dependencies are inferred from the claim text.