Back to results
US 6,663,901 B1Granted
Pellets having a core coated with an antifungal and a polymer
AssigneeJanssen Pharmaceutical N.V.
InventorsPaul Marie Victor Gilis, Valentin Florent Victor De Conde, Roger Petrus Gerebern Vandecruys
Life of this patent
Estimating the term…
Abstract
The present invention is concerned with pellets comprising a 710-1180 μm (16-25 mesh) sugar core, a coating film of a water-soluble polymer and an antifungal agent, and a seal coating layer wherein the residual concentration of dichloromethane is below 600 ppm; pharmaceutical dosage forms comprising said pellets and a method of preparing said pellets.
Claims2
A process for preparing pellets, each of said pellets comprising
- a central, rounded or spherical core having a diameter from about 710 to about 1180 μm (16-25 mesh);
- a coating film of a water-soluble polymer and an antifungal agent, and
- a seal-coating polymer layer,
- wherein the process comprises
- a) coating sugar cores by spraying them with a solution of an antifungal agent and a water-soluble polymer in an organic solvent comprising methylene chloride and an alcohol in a fluidized-bed granulator equipped with a bottom spray insert;
- b) drying the resulting coated cores in vacuo by irradiating said cores with microwave or radiofrequency radiation;
- and
- c) seal-coating the dried cores by spraying them with a solution of a seal-coating polymer in an organic solvent comprising methylene chloride and an alcohol in a fluidized-bed granulator equipped with a bottom spray insert,
- wherein said pellets have a residual concentration of dichloromethane of less than 600 ppm.
6 more elements
Dependencies are inferred from the claim text.