Intraocular transplantation of encapsulated cells
AssigneesUniversite de Paris V Rene-Descartes, Association Francaise Retinitis Pigmentosa
InventorsMarc Abitbol, Yves Uteza, Maurice Menasche, Carine Bossard, Loic Van Den Berghe, Sebastian Bonnel, Hervé Prats, Jiri Honiger, Martin Neuner-Jehle
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Abstract
Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. The encapsulation prevents the entry of host immune cells in the microcapsule while permitting the release of the polypeptide outside of the microcapsule.
Claims8
A composition comprising encapsulated cells which produce an endostatin or a fibroblast growth factor polypeptide, wherein said encapsulated cells are encapsulated with a biocompatible material of polyacrylonitril-methysulfonate.
Dependencies are inferred from the claim text.