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US 6,663,893 B2Granted
Taste masking coating composition
AssigneeBristol-Myers Squibb Company
InventorsMichael Corbo, Jatin Desai, Mahesh Patell, Ronald Warrick
Life of this patent
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Abstract
There is provided a coating composition that masks the undesirable taste of a pharmaceutically active ingredient, i.e. drug or medicine, that is taken orally. The coating composition is comprised of dimethylaminoethyl methacrylate and neutral methacrylic acid ester, a cellulose ester polymer, and an alkaline modifier.
Claims23
A coating composition for masking the taste of a drug active ingredient or medicine and enhancing release of the drug or medicine in the stomach, comprising:
- an effective amount of a taste masking blend of
- (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester;
- (b) a cellulose ester polymer;
- and
- (c) about 0.2 wt. % to about 20 wt. % of an alkaline modifier selected from the group consisting of triethanolamine, basic amino acids, talc, ammonium oleate, meglumine, trimethylamine, calcium silicate, aluminum magnesium silicate, food alkalizing agent, and mixture thereof;
- wherein the amount of alkaline modifier is based on the total weight of the composition, and to increase the coating composition's dissolution rate in the stomach, as compared to a like coating composition that does not contain the alkaline modifier.
3 more elements
A medicament composition comprising:
- a drug ingredient;
- and
- a coating composition for masking the taste of the drug ingredient, the drug ingredient being coated by the coating composition, the coating composition comprising:
- an effective amount of a taste masking blend of
- (a) dimethylaminoethyl methacrylate and neutral methacrylic acid ester;
- (b) a cellulose ester polymer;
- and
- (c) about 0.2 wt. % to about 20 wt. % of an alkaline modifier selected from the group consisting of triethanolamine, basic amino acids, talc, ammonium oleate, meglumine, trimethylamine, calcium silicate, aluminum magnesium silicate, food alkalizing agent, and mixture thereof;
- wherein the amount of alkaline modifier is based on the total weight of the composition, and to increase the dissolution rate of the coating in the stomach, as compared to a like coating composition that does not contain the alkaline modifier.
6 more elements
Dependencies are inferred from the claim text.