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US 6,663,891 B2Granted
Erythromyacin antibiotic product, use and formulation thereof
AssigneeAdvancis Pharmaceutical Corp.
InventorsEdward M. Rudnic, James D. Isbister, Donald J. Treacy, Jr., Sandra E. Wassink
Life of this patent
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Abstract
An antibiotic product, in particular an erythromyacin, is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
Claims38
A once-a-day antibiotic product comprising:
- first, second, and third dosage forms;
- each of said dosage forms comprising an erythromyacin and a pharmaceutically acceptable carrier;
- said first dosage form being an immediate release dosage form;
- said second and third dosage forms being delayed release dosage forms;
- wherein each of said first, second, and third dosage forms initiates release of the erythromyacin at different times;
- wherein Cmax of the total erythromyacin released from said product is achieved in less than about 12 hours from administration;
- and wherein said once-a-day product contains the total dosage of the erythromyacin for a twenty-four hour period.
4 more elements
A once-a-day antibiotic product comprising:
- first, second, and third dosage forms;
- each of said dosage forms comprising clarithromycin and a pharmaceutically acceptable carrier;
- said first dosage form being an immediate release dosage form;
- said second and third dosage forms being delayed release dosage forms;
- wherein each of said first, second, and third dosage forms initiates release of erythromyacin at different times;
- wherein Cmax of the total erythromyacin released from said product is achieved in less than about 12 hours from administration;
- and wherein said once-a-day product contains the total dosage of erythromyacin for a twenty-four hour period.
4 more elements
Dependencies are inferred from the claim text.