Aqueous liposome system and a method for the preparation of such a liposome system
AssigneeA. Natterman & Cie. GmbH
InventorsJörg-Christian Hager, Josef-Peter Löhr, Manfred Dürr
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Abstract
An aqueous liposome system comprises at least one phospholipid, a non-phospholipidic substance which is a bile acid or derivative thereof, and, optionally, a non-toxic organic solvent. The mass ratio of phospholipid to the non-phospholidic substance is in the range between 1:0.001 and 1:0.1. The diameter of the liposomes formed in this liposome system is in the range between 35 and 90 nm. The liposome system is stable over large periods of time, e.g., several months or years, and is highly transparent. The liposomes may be loaded with a pharmaceutically active ingredient.
Claims12
An aqueous liposome system comprising at least one phospholipid, a non-phospholipidic substance selected from the group consisting of cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, glycocholic acid, taurocholic acid, and their respective sodium and ammonium salts, and, optionally, a non-toxic organic solvent, the mass ratio of said phospholipid to said non-phospholipidic substance being in the range between 1:0.001 and 1:0.1, wherein the diameter of liposomes in said liposome system is in the range between 35 and 90 nm.
Dependencies are inferred from the claim text.