Therapeutic inhibitor of vascular smooth muscle cells
AssigneeNeoRx Corporation
InventorsLawrence L. Kunz, John M. Reno
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Abstract
Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
Claims13
A method to inhibit or reduce vascular remodeling of a traumatized mammalian blood vessel, which method comprises administering to the blood vessel a cytostatic amount of a cytoskeletal inhibitor effective to inhibit or reduce vascular remodeling of the traumatized vessel, wherein the vascular remodeling is characterized by constriction of the interior lumen diameter or area of the vessel, and wherein the amount inhibits vascular smooth muscle cell proliferation.
Dependencies are inferred from the claim text.