Anti-inflammatory bioactive glass particulates
AssigneeUSBiomaterials Corporation
InventorsDavid C. Greenspan, Sean Lee, Marlo tan Walpole
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Abstract
Compositions and methods for systemically minimizing the inflammatory effects of TNF-α are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20 μm, alone or in combination with anti-inflammatory agents and other therapeutic agents. The compositions can include an appropriate carrier for oral, intramuscular, intraperitoneal or intravenous administration. When administered to a patient, the particles bring about elevated levels of IL-6 and do not cause elevated levels of TNF-α.
Claims11
A method for minimizing the production of TNF-α caused by an inflammatory response in a patient comprising administering locally a locally effective TNF-α lowering amount of bioactive glass particles with a size less than about 20 μm to the patient.
Dependencies are inferred from the claim text.