Antigenic preparation for treatment or prevention of helicobacter infection
AssigneeCSL Limited
InventorsChristopher Vincent Doidge, Adrian Lee, Fiona Jane Buck, Elizabeth Pietrzykowski, Charles Alexander Quinn, Ian George Barr, Michael John Kleinig
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Abstract
An antigenic preparation for use in the treatment or prevention of Helicobacter infection in a mammalian host, comprises the lipopolysaccharide (LPS) of Helicobacter bacteria, particularly the LPS of H. pylori or H. felis, or an immunogenic fragment thereof.
Claims14
A composition for use in the treatment or prevention of Helicobacter pylori or Helicobacter felis infection in a mammalian host by eliciting a mucosal immune response in said host, which composition comprises (A) an immunologically effective amount of an antigenic preparation comprising an at least partially purified lipopolysaccharide (LPS) of Helicobacter bacteria or an immunogenic fragment thereof which elicits said mucosal immune response, (B) a compound with adjuvant activity and (C) one or more pharmaceutically acceptable carriers or diluents.
A method for the treatment or prevention of Helicobacter pylori or Helicobacter felis infection in a mammalian host by eliciting a mucosal immune response in said host, comprising administering to said host an immunologically effective amount of an antigenic preparation comprising an at least partially purified lipopolysaccharide (LPS) of Helicobacter bacteria, or an immunogenic fragment thereof, to elicit said mucosal immune response.
Dependencies are inferred from the claim text.