Back to results
US 6,663,864 B1Granted
Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
AssigneePromega Corporation
InventorsJohn A. Kink, Katherine L. Worledge, Douglas C. Stafford
Life of this patent
Estimating the term…
Abstract
Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human therapy for the treatment of colitis, including Crohn's disease.
Claims20
A method of treatment, comprising:
- a) providing:
- i) a mammal having a symptom of inflammatory bowel disease, wherein said symptoms are associated with diseases selected from the group consisting of ulcerative colitis, proctitis, and Crohn's disease,
- ii) a therapeutic enteric formulation comprising avian polyclonal antibodies directed to TNF, and;
- b) orally administering said formulation to said mammal under conditions such that said symptom is reduced.
1 more element
A method of treatment, comprising:
- a) providing:
- i) a human patient with a symptom of inflammatory bowel disease,
- ii) a therapeutic formulation comprising polyclonal antibodies directed to IL-6, and;
- b) orally administering said formulation to said patient under conditions such that said symptom is reduced.
1 more element
A method of treatment, comprising:
- a) providing:
- i) a human patient with a symptom of Crohn's disease,
- ii) a therapeutic formulation comprising polyclonal antibodies directed to IL-6, and;
- b) orally administering said formulation to said patient under conditions such that said symptom is reduced.
1 more element
Dependencies are inferred from the claim text.