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OwnerYan-Fei Shen, Richard Oryszczak +1inventors
InventorsYan-Fei Shen, Richard Oryszczak, Angel L. Carrillo
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Disclosed are enhanced efficacy aluminum-zirconium chlorohydrate antiperspirant salts having a metal (Al+Zr) to chloride ratio of about 0.9 to about 1.2, preferably about 0.9 to about 1.1, most preferably about 0.9 to about 1.0. To achieve the highest possible antiperspirant efficacy, these salts are made with or include a zirconium hydroxychloride of the formula Zr(OH)4−bClb wherein b is about 2.8 to about 4.0, preferably about 3.2 to about 4.0, so that the Zr:Cl ratio in said zirconium hydroxychloride is about 0.36 to about 0.25, preferably about 0.31 to about 0.25. The present invention also embraces methods of making such antiperspirant salts and aqueous solutions of such antiperspirant salts. The present invention further embraces topical compositions comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt as described above.
An aluminum-zirconium chlorohydrate having a metal (Al+Zr) to chloride ratio of about 0.9 to about 1.2, wherein said aluminum-zirconium chlorohydrate is made with a zirconium hydroxychloride of the formula Zr(OH)4−bClb wherein b is 2.8 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is 0.36 to 0.25.
A method of preparing an aluminum-zirconium chlorohydrate of the formula AlnZr(OH)[3n+4−m(n+1)](Cl)[m(n+1)] wherein n is 2.0 to 10.0 and m is 0.83 to 1.11, which method comprises mixing in an aqueous solution an aluminum antiperspirant salt with a zirconium hydroxychloride salt of the formula Zr(OH)4−bClb wherein b is 2.8 to 4.0, each salt being present in an amount to provide an Al:Zr molar ratio of 2.0 to 10.0, and, if necessary, adjusting the metal (Al+Zr) to chloride ratio (M:Cl) to 0.9 to 1.2 by inclusion of an appropriate amount of a chloride ion source in the aqueous solution.
A method of preparing an aluminum-zirconium chlorohydrate of the formula AlnZr(OH)[3n+m(n+1)](Cl)[m(n+1)] wherein n is 2.0 to 10.0 and m is 0.83 to 1.11, which method comprises dry blending an aluminum antiperspirant salt with a zirconium hydroxychloride salt of the formula Zr(OH)4−bClb wherein b is 2.8 to 4.0, each salt including a sufficient molar amount of Al, Zr and Cl and being present in an amount to provide an Al:Zr molar ratio of 2.0 to 10.0 and a metal (Al+Zr) to chloride ratio (M:Cl) of 0.9 to 1.2.
An aluminum-zirconium chlorohydrate having a metal (Al+Zr) to chloride ratio of about 0.9 to about 1.2, wherein said aluminum-zirconium chlorohydrate includes a zirconium hydroxychloride of the formula Zr(OH)4−bClb wherein b is 2.8 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is 0.36 to 0.25.
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