HIV and CD4 transgenic animals and uses therefor
AssigneeUniversity of Maryland Biotechnology Institute
InventorsJoseph L. Bryant, William C. Reid, Harry G. Davis, Jr.
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Abstract
The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds for preventing lentiviral infection and treating associated disease (e.g. AIDS).
Claims9
A transgenic rat, whose genome comprises at least one copy of an immunodeficiency virus (HIV-1) proviral DNA, wherein the gag and pol genes are mutated to render the proviral DNA noninfectious and a non-HIV-1 transgene, wherein the non-HIV-1 transgene encodes a full length CD4 protein that mediates cellular entry of HIV-1, and wherein said transgenic rat develops at least one symptom of Acquired Immune Deficiency Syndrome (AIDS).
Dependencies are inferred from the claim text.