Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom
AssigneeInsmed Incorporated
InventorsLeland L. Johnson, Jr., Mark C. Sleevi, A. S. Campbell, Robert Plourde, Patrick Leonard, Paul Miller
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Abstract
The present invention relates to methods for the production and isolation of D-chiro-inositol (DCI) from plant extracts. Specifically the present invention provides a method to produce D-chiro-inositol from a precursor moiety by conversion in concentrated hydrochloric acid. More specifically, the present invention relates to a method for the efficient production of DCI by a process involving the extraction of D-pinitol from soy hulls followed by conversion thereof to DCI.
Claims12
A method to produce D-chiro-inositol comprising:
- (a) preparing a reaction solution comprising a crude plant extract comprising a D-chiro-inositol precursor containing a D-chiro-inositol moiety selected from the group consisting of D-chiro-inositol, D-pinitol, ciceritol, 1D-2-O-alpha-D-galactopyranose-chiro-inositol, and fagopyritols in a solution of about 9 N to 12 N HCl;
- and
- (b) reacting the solution of step (a) at a temperature in the range of about 65° C. to about 110° C. for a period of time sufficient to convert the D-chiro-inositol precursor to D-chiro-inositol.
A method to produce D-chiro-inositol comprising:
- (a) preparing a reaction solution comprising a crude plant extract containing one or more carbohydrates or oligosaccarides, wherein the extract comprises a D-chiro-inositol moiety selected from the group consisting of D-chiro-inositol, D-pinitol, ciceritol, 1D-2-O-alpha-D-galactopyranose-chiro-inositol, and fagopyritols, in a solution of about 9 N to 12 N HCl;
- and
- (b) reacting the solution of step (a) at a temperature in the range of about 90° C. to about 110° C. for a period of time sufficient to convert the D-chiro-inositol moiety to D-chiro-inositol.
Dependencies are inferred from the claim text.