Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade

A compound of the Formula:

• or a pharmaceutically acceptable salt thereof, wherein;
• J is selected from the group consisting of halo, haloalkyl, hydroxy, hydroxyalkyl, amino, aminoalkyl, cyano, O—R6, NH—R6, and S—R6, wherein R6 is alkyl or haloalkyl;
• B is selected from the group consisting of hydrido, C2-C8 alkyl, C3-C8 alkenyl, C3-C8 alkynyl, and C2-C8 haloalkyl, wherein each member of group B is optionally substituted at any carbon up to and including 6 atoms from the point of attachment of B to A with one or more of the group consisting of R32, R33, R34, R35, and R36;
• R32, R33, R34, R35, and R36 are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkoxy, hydroxy, amino, alkoxyamino, alkylamino, alkylthio, amidosulfonyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboalkoxy, carboxy, carboxamido, cyano, and Qb;
• A is a bond or (CH(R15))pa—(W7)rr wherein rr is 0 or 1, pa is an integer selected from 0 through 3, and W7 is (R7)NC(O) or N(R7);
• R7 is selected from the group consisting of hydrido, hydroxy and alkyl;
• R15 is selected from the group consisting of hydrido, halo, alkyl, and haloalkyl;
• R1 and X0 are independently selected from the group consisting of hydrido, hydroxy, hydroxyamino, amidino, amino, cyano, hydroxyalkyl, alkoxy, alkyl, alkylamino, aminoalkyl, alkylthio, alkoxyamino, haloalkyl, haloalkoxy, and halo;
• R2 is Z0-Q;
• Z0 is selected from the group consisting of a bond, OH2, CH2CH2, W0—(CH(R42))p wherein p is 0 or 1 and W0 is selected from the group consisting of O, S, and N(R41);
• R41 and R42 are independently hydrido or alkyl;
• Q is phenyl or a heteroaryl of 5 or 6 ring members, wherein a carbon adjacent to the carbon at the point of attachment of said phenyl or heteroaryl ring to Z0 is optionally substituted by R9, the other carbon adjacent to the carbon at the point of attachment is optionally substituted by R13, a carbon adjacent to R9 and two atoms from the carbon at the point of attachment is optionally substituted by R10, a carbon adjacent to R13 and two atoms from the carbon at the point of attachment is optionally substituted by R12, and any carbon adjacent to both R10 and R12 is optionally substituted by R11;
• R9, R11, and R13 are independently selected from the group consisting of hydrido, hydroxy, amino, amidino, guanidino, alkylamino, alkylthio, alkylsulfonamido, alkylsulfinyl, alkylsulfonyl, amidosulfonyl, alkyl, alkoxy, halo, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyhaloalkyl, carboxy, carboxamido, and cyano;
• R10 and R12 are independently selected from the group consisting of hydrido, acetamido, haloacetamido, amidino, guanidino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, alkoxy, cycloalkoxy, cycloalkylalkoxy, aralkoxy, aryloxy, heteroaryloxy, heteroaralkoxy, heterocyclyloxy, heterocyclylalkoxy, hydroxy, amino, alkoxyamino, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, heterocyclylamino, heterocyclylalkylamino, alkylsulfonamido, amidosulfonyl, arylsulfinyl, aralkylsulfinyl, cycloalkylsulfinyl, heteroarylsulfinyl, arylsulfonyl, aralkylsulfonyl, cycloalkylsulfonyl, heteroarylsulfonyl, hydroxyalkyl, hydroxyhaloalkyl, aminoalkyl, carboalkoxy, carboxy, carboxyalkyl, carboxamido, halo, haloalkyl, and cyano;
• Y0 is phenyl or a heteroaryl of 5 or 6 ring members, wherein one carbon of said phenyl or said heteroaryl is substituted by Qs, a carbon two or three atoms from the point of attachment of Qs to said phenyl or said heteroaryl is substituted by Qb, a carbon adjacent to the point of attachment of Qs is optionally substituted by R17, another carbon adjacent to the point of attachment of Qs is optionally substituted by R18, a carbon adjacent to Qb is optionally substituted by R16, and another carbon adjacent to Qb is optionally substituted by R19;
• R16, R17, R18, and R19 are independently selected from the group consisting of hydrido, amidino, guanidino, carboxy, haloalkylthio, alkoxy, hydroxy, amino, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyl, haloalkanoyl, alkyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, aminoalkyl, and cyano;
• R16 or R19 is optionally selected from the group consisting of NR20R21, N(R26)C(NR25)N(R23)(R24), and C(NR25)NR23R24, with the proviso that R16, R19, and Qb are not simultaneously hydrido;
• Qb is selected from the group consisting of NR20R21, hydrido, C(NR25)NR23R24, and N(R26)C(NR25)N(R23)(R24), with the proviso that no more than one of R20 and R21 is hydroxy at the same time and with the further proviso that no more than one of R23 and R24 is hydroxy at the same time;
• R20, R21, R23, R24, R25, and R26 are independently selected from the group consisting of hydrido, alkyl, and hydroxy;
• Qs is selected from the group consisting of a bond, CH2, and CH2CH2.