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US 6,660,866 B2Granted
C10 carbonate substituted taxanes
AssigneePSU Research Foundation, Inc.
InventorRobert A. Holton
Life of this patent
Estimating the term…
Abstract
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
Claims117
A taxane having the formula:
- wherein
- R2 is acyloxy;
- R7 is hydroxy;
- R9 is keto, hydroxy, or acyloxy;
- R10 is carbonate;
- R14 is hydrido or hydroxy;
- X3 is substituted or unsubstituted heterocyclo;
- X5 is —COX10, —COOX10, or —CONHX10;
- X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
- and
- Ac is acetyl.
8 more elements
A taxane having the formula
- R2 is benzoyloxy;
- R7 is hydroxy;
- R10 is R10aOCOO—;
- X3 is substituted or unsubstituted heterocyclo;
- X5 is —COX10, —COOX10, or —CONHX10;
- X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
- and
- R10a is hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
- and
- Ac is acetyl.
7 more elements
A taxane having the formula
- R2 is benzoyloxy;
- R7 is hydroxy;
- R10 is R10aOCOO—;
- X3 is heterocyclo;
- X5 is —COX10, —COOX10, or —CONHX10;
- X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
- and
- R10a is alkyl, alkenyl, alkynyl, phenyl, or heterocyclo wherein alkyl comprises at least two carbon atoms;
- and
- Ac is acetyl.
7 more elements
Dependencies are inferred from the claim text.