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US 6,660,862 B2Granted
Polyketide synthase enzymes and recombinant DNA constructs therefor
AssigneeKosan Biosciences, Inc.
InventorsChristopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu
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Abstract
Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
Claims46
A polyketide having the structure
- wherein, R1 is hydrogen, methyl, ethyl, or allyl;
- R2 is hydrogen or hydroxyl, provided that when R2 is hydrogen, there is a double bond between C-20 and C-19;
- R3 is hydrogen or hydroxyl;
- R4 is methoxyl, hydrogen, methyl, or ethyl;
- and R5 is methoxyl, hydrogen, methyl, or ethyl;
- but not including FK-506, FK-520, 18-hydroxy-FK-520, and 18-hydroxy-FK-506.
3 more elements
A compound of the formula
- wherein:
- R1 is ethyl or allyl;
- R2 is hydrogen and there is a double bond between C-20 and C-19;
- R3 is hydrogen;
- R4 is methoxyl, hydrogen, methyl, or ethyl;
- and
- R5 is methoxyl, hydrogen, methyl, or ethyl;
- provided that at least one or R4 or R5 is not methoxyl.
5 more elements
A compound of the formula
- wherein:
- R1 is ethyl or allyl;
- R2 is hydrogen and there is a double bond between C-20 and C-19;
- R3 is hydroxyl;
- R4 is methoxyl, hydrogen, methyl, or ethyl;
- and
- R5 is methoxyl, hydrogen, methyl, or ethyl;
- provided that at least one or R4 or R5 is not methoxyl.
5 more elements
Dependencies are inferred from the claim text.