Crystals of penicillin and process for the production thereof
AssigneesOtsuka Chemical Co., Ltd., Taiho Pharmaceutical Co., Ltd.
InventorsAkihiro Shimabayashi, Ichiro Kawahara
Life of this patent
Estimating the term…
Abstract
The crystal of the invention is crystal of diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate which is stable substantially without decomposition or degradation of properties even when left to stand at room temperature for 1 year. The crystal of the invention can be prepared by a process comprising the steps of concentrating a solution containing diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate represented by the formula (2) wherein Ph is a phenyl group, diluting the concentrate with acetic ester and mixing the diluted solution with hexane or a solvent mixture of hexane and acetic ester to crystallize the diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate.
Claims1
A process for preparing the crystalline diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate, the process comprising the steps of concentrating a solution containing diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate represented by the formula (2):
- wherein Ph is a phenyl group, diluting the concentrate with an acetic ester, and mixing the diluted solution with hexane or a solvent mixture of hexane and an acetic ester to crystallize the diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate.
Dependencies are inferred from the claim text.