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US 6,660,854 B2Granted
Processes for preparing β-D-ribofuranose derivatives
AssigneeYuhan Corporation
InventorsTai-Au Lee, Nam-Jin Park, Ja-Heouk Khoo, Byung-Cheol Lee
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Abstract
Provided are a process for preparing β-D-ribofuranose derivatives, which are useful as an intermediate for the preparation of ribavirin. The process can be performed under a mild condition, in the presence of a catalyst selected from the group consisting of methanesulfonic acid, benzenesulfonic acid and p-toluenesulfonic acid.
Claims13
A process for preparing a β-D-ribofuranose compound of formula (I), which comprises the steps of:
- (a) reacting a compound of formula (II) with a compound of formula (III) at about 90° C. to 100° C., in the presence of a catalyst selected from the group consisting of methanesulfonic acid, benzenesulfonic acid and p-toluenesulfonic acid;
- and
- (b) crystallizing the resulting compound obtained in step (a):
- wherein R1 is a protecting group for hydroxyl group;
- and R2 is a C1-C4 alkyl group.
2 more elements
Dependencies are inferred from the claim text.