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US 6,660,842 B1Granted
Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
AssigneeTripep AB
InventorMatti Sällberg
Life of this patent
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Abstract
The present invention generally relates to compositions and methods for preventing and treating human diseases including, but not limited to, pathogens such as bacteria, yeast, parasites, fungus, viruses, and cancer. More specifically, embodiments described herein concern the manufacture and use of ligand/receptor specificity exchangers, which redirect existing antibodies in a subject to receptors present on pathogens.
Claims34
A ligand/receptor specificity exchanger comprising:
- at least one specificity domain comprising a first peptide, which comprises a ligand for a receptor;
- and
- at least one antigenic domain joined to said specificity domain, wherein said antigenic domain comprises a second peptide, which comprises an epitope of a pathogen or toxin and wherein said first and second peptides are from different proteins.
A ligand receptor specificity exchanger comprising:
- at least one specificity domain comprising a ligand for a receptor;
- and
- at least one antigenic domain joined to said specificity domain, wherein said antigenic domain comprises an epitope of a pathogen or toxin and wherein the sequence of said ligand/receptor specificity exchanger is selected from the group consisting of SEQ. ID. No. 60, SEQ. ID. No. 61, SEQ. ID. No. 62, SEQ. ID. No. 63, SEQ. ID. No. 64, SEQ. ID. No. 65, SEQ. ID. No. 66, SEQ. ID. No. 67, SEQ. ID. No. 68, SEQ. ID. No. 69, SEQ. ID. No. 70, SEQ. ID. No. 71, SEQ. ID. No. 72, SEQ. ID. No. 73, SEQ. ID. No. 74, SEQ. ID. No. 75, SEQ. ID. No. 76, SEQ. ID. No. 77, SEQ. ID. No. 78, SEQ. ID. No. 79, SEQ. ID. No. 80, SEQ. ID. No. 81, SEQ. ID. No. 82, SEQ. ID. No. 83, SEQ. ID. No. 84, SEQ. ID. No. 85, SEQ. ID. No. 86, SEQ. ID. No. 87, SEQ. ID. No. 88, SEQ. ID. No. 89, SEQ. ID. No. 90, SEQ. ID. No. 91, SEQ. ID. No. 92, SEQ. ID. No. 93, SEQ. ID. No. 94, SEQ. ID. No. 95, SEQ. ID. No. 96, SEQ. ID. No. 97, SEQ. ID. No. 98, SEQ. ID. No. 99, SEQ. ID. No. 100, SEQ. ID. No. 101, SEQ. ID. No. 102, SEQ. ID. No. 103, SEQ. ID. No. 104, and SEQ. ID. No. 105.
Dependencies are inferred from the claim text.