Methods for enhancement of protective immune responses
AssigneeCorixa Corporation
InventorSteven G. Reed
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Abstract
Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.
Claims4
An isolated polypeptide comprising SEQ ID NO:
- 4.
An isolated polypeptide comprising amino acids 49-403 of SEQ ID NO:
- 4.
An isolated polypeptide comprising a portion of SEQ ID NO:
- 4, wherein the portion possesses the ability to stimulate a Th1 response in peripheral blood mononuclear cells.
Dependencies are inferred from the claim text.