Modified protein derived from protein kinase N
AssigneeKirin Beer Kabushiki Kaisha
InventorsKozo Kaibuchi, Yoshitaka Ono, Akihiro Iwamatsu
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Abstract
A object of the present invention is to provide a peptide inhibiting tumorigenesis or metastasis. The present invention is a peptide or derivatives thereof comprising a modified amino acid sequence of Protein Kinase N having the activated Rho protein binding activity and not having protein kinase activity, and a peptide or derivatives thereof comprising a modified amino acid sequence of Protein Kinase N inhibiting the protein kinase activity of Protein Kinase N or the enhancement of the activity and not having protein kinase activity.
Claims5
An isolated peptide having activated Rho protein binding activity and not having protein kinase activity, consisting of a peptide fragment of the amino acid sequence 1-613 of SEQ ID NO:3.
An isolated peptide having intermediate filament binding activity and not having protein kinase activity, consisting of a peptide fragment of the amino acid sequence 1-613 of SEQ ID NO:3.
Dependencies are inferred from the claim text.