Lead substances and their use as therapeutics
AssigneeFriedrich Goetz
InventorsMichael Otto, Roderich Suessmuth, Guenther Jung, Friedrich Goetz
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Abstract
The present invention relates to peptides, which are useful in treating Staphylococcus infections. More particularly, the inventive peptides interfere with the regulation of the agr system of Staphylococcus species, especially S. aureus, and thereby block the formation of different virulence factors. The inventive peptides comprise at least the amino acid sequence S V X A S Y F, whereby cyclic structures of that kind of peptides are the most potent blocking reagents.
Claims16
A peptide comprising the following amino acid sequence
- S V X A S Y F (SEQ ID NO:
- 18),
- wherein X is a serine.
A peptide comprising the following amino acid sequence
- S V X A S Y F (SEQ ID NO:18),
- wherein X is 1,3-diamino-propionic acid.
A peptide comprising the following amino acid sequence
- S V C A S Y F (SEQ ID NO:18),
- wherein an intramolecular cyclic bond with a thiolactone structure is located between the central cysteine and the C-terminal carboxy group.
A peptide comprising the following amino acid sequence
- S V C A S Y F (SEQ ID NO:18),
- wherein said peptide is a cyclic heptapeptide having the amino acid sequence
- S V c[C A S Y F] (SEQ ID NO:18).
A peptide comprising the following amino acid sequence,
- S V C A S Y F (SEQ ID NO:18),
- wherein said peptide is a cyclic octapeptide having the amino acid sequence
- D S V c [C A S Y F] (SEQ ID NO:19).
A peptide comprising the following amino acid sequence,
- S V S A S Y F (SEQ ID NO:18),
- wherein said peptide is a cyclic octapeptide having the amino acid sequence
- D S V c [S A S Y F] (SEQ ID NO:19).
A peptide comprising the following amino acid sequence,
- S V X A S Y F (SEQ ID NO:18),
- wherein X is 1,3-diamino-propionic acid and said peptide is a cyclic octapeptide having the amino acid sequence
- D S V c [X A S Y F] (SEQ ID NO:19), wherein X is 1,3-diamino-propionic acid.
A peptide comprising the following amino acid sequence,
- S V C A S Y F (SEQ ID NO:18),
- wherein said peptide is a cyclic nonapeptide having the amino acid sequence
- G D S V c[C A S Y F] (SEQ ID NO:17).
Dependencies are inferred from the claim text.