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US 6,660,830 B1Granted
Peptides with antiproliferative properties
OwnerRazvan T Radulescuinventor
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Abstract
The present invention relates to antiproliferative peptides which are derived from a tumor suppressor protein and bind to growth factor segments or growth factor receptor segments. The invention also relates to nucleic acids (DNAs/RNAs) which code for these peptides and structurally homologous peptide nucleic acids and pharmaceutical compositions containing such peptides. The invention can be used in biotechnology, molecular biology, bioinformatics and in the diagnosis and therapy of hyperproliferative disorders, in particular cancer and atherosclerosis.
Claims14
An antiproliferative peptide AB or BA consisting of:
- an antiproliferative component (A) that is a fragment of a tumor suppressor protein or a peptide sequence hydropathically homologous thereto having the property of binding to a growth factor segment or to a growth factor receptor segment, and
- a component (B) that protects component (A) from the proteolytic degradation by proteases, and that is a nuclear localization sequence (NLS) selected from the group consisting of
- a) the amino acid sequence PKKKRKV (SEQ. ID. No. 21),
- b) the amino acid sequence RQIKIWFQNRRMKWKK (SEQ. ID. No. 22),
- c) a bipartite nuclear localization sequence (“NLS”), and
- d) the RNP A1 NLS;
- wherein the antiproliferative peptide is cytotoxic to tumor cells.
4 more elements
Dependencies are inferred from the claim text.