N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of γ-aminobutyric acid activity and for treating nervous disorders and preparation method

A process for the preparation of the compound of following general formula I:

• in which:
• Z represents a sulfur or oxygen atom,
• the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• X represents a CO, a CO2, an SO or an SO2,
• and the R group represents an alkyl, aryl, alkenyl or aralkyl group,
• characterized in that the amine of the compound of general formula:
• in which:
• Z represents a sulfur or oxygen atom,
• and the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• is treated with an appropriate reactant to produce the compounds of general formula I.

A pharmaceutical composition comprising a compound of following general formula:

• in which:
• Z represents a sulfur or oxygen atom,
• the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• X represents a CO, a CO2, an SO or an SO2,
• and the R group represents an alkyl, aryl, alkenyl or aralkyl group,
• and an appropriate pharmaceutical carrier.

Method of using of the compounds of following general formula:

• as stimulant of the activity of Y-aminobutyric acid acting via GABA-A receptor of the central nervous system in which:
• Z represents a sulfur or oxygen atom,
• the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• X represents a CO, a CO2, an SO or an SO2,
• and the R group represents an alkyl, aryl, alkenyl or aralkyl group.

A medicament comprising a compound of following general formula:

• in which:
• Z represents a sulfur or oxygen atom,
• the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• X represents a CO, a CO2, an SO or an SO2,
• and the R group represents an alkyl, aryl, alkenyl or aralkyl group.

Method of using the compounds of following general formula for the treatment of nervous disorders:

• for the treatment of nervous disorders in which:
• Z represents a sulfur or oxygen atom,
• the R1 and R2 groups, which can be identical to or different from one another, each represent an alkyl group or an alkenyl group,
• X represents a CO, a CO2, an SO or an SO2,
• and the R group represents an alkyl, aryl, alkenyl or aralkyl group.