Bis-indolylquinone compounds
AssigneeSugen, Inc.
InventorsPeng Cho Tang, Gerald McMahon, G. Davis Harris, Jr., Ken Lipson
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AssigneeSugen, Inc.
InventorsPeng Cho Tang, Gerald McMahon, G. Davis Harris, Jr., Ken Lipson
Estimating the term…
The present invention relates to a class of indolylquinone compounds that inhibit GRB-2 adaptor protein function, pharmaceutical compositions comprising these compounds, and methods for ameliorating the symptoms of cell proliferative disorders associated with GRB-2 adaptor protein function using these compounds. The present invention further relates to methods for treating insulin-related disorders, such as diabetes, insulin resistance, insulin deficiency and insulin allergy, and for ameliorating the symptoms of insulin-related disorders, using certain indolylquinone compounds and pharmaceutical compositions thereof. The present invention also relates to novel synthetic methods for the preparation of mono- and bis-indolylquinone compounds.
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Dependencies are inferred from the claim text.