US 6,660,761 B2 · Method of treatment for fungal infections with a synergistic formulation of antifungal agents

Method of treatment for fungal infections with a synergistic formulation of antifungal agents

AssigneeCouncil of Scientific and Industrial Research

InventorsSuman Preet Singh Khanuja, Puspalata Chatruvedi, Krishna Kumar Agarwal, Atique Ahmad, Tiruppadiripuliyur Ranganathan Santha Kumar, Mahendra Pandurang Darokar, Ajit Kumar Shasany, Jai Shankar Arya, Sushil Kumar

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Abstract

The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of antifungal compounds. The plant compounds, menthol and menthyl acetate, when mixed at specific concentrations, enhance the antifungal activity of the commercially available fungicides.

Claims18

Dependent claims

A method of treating fungal infection comprising administering an effective amount of a bioactive synergistic formulation which consists essentially of:

(a) Menthol in the range of 1-54%;
(b) Menthyl acetate in the range of 1.5-62%;
and
(c) an antifungal compound in the range of 23-95%.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/066,802Filed 6 Feb 2002

Published

US 2003/0158126 A121 Aug 2003

Granted

9 Dec 2003

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Classification8 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 31/045
Medicinal preparations containing organic active ingredients: hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/22
Of carboxylic acids: of acyclic acids, e.g. pravastatin
A61K 31/222
Of acyclic acids, e.g. pravastatin: with compounds having aromatic groups, e.g. dipivefrine, ibopamine