Inhibition of glycolipid biosynthesis
AssigneeThe Chancellor, Masters and Scholars of the University of Oxford
InventorsTerry D. Butters, Frances M. Platt, Raymond A. Dwek
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Abstract
Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
Claims11
A method of treating a lysosomal lipid storage disease selected from Tay-Sachs disease, Gaucher disease, Krabbe disease, or Fabry disease, comprising administering an effective amount of N-nonyl-1,5-dideoxy-1,5-imino-D-glucitol to a subject with the lysosomal lipid storage disease.
Dependencies are inferred from the claim text.