Bicyclic derivatives

A compound having formula (I) or formula (II):

• and pharmaceutically acceptable derivatives thereof, wherein:
• X is O, S, C(R1)2 or NR1;
• y is 2;
• A and B are independently E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl;
• wherein 1 or 0.72 hydrogen atoms in said alkyl, alkenyl or alkynyl are independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl;
• and wherein 1 to 2 methylene (—CH2—) groups in said alkyl, alkenyl, or alkynyl groups are optionally and independently replaced by —O—, —S—, —S(O)—, —S(O)2—, ═N—, —N═ or —N(R3)—;
• R1 is E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl;
• wherein 1 or 2 hydrogen atoms in said alkyl, alkenyl or alkynyl are optionally and independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl;
• and wherein 1 to 2 methylene (—CH2—) groups in said alkyl, alkenyl, or alkynyl groups are optionally and independently replaced by —O—, —S—, —S(O)—, —S(O)2—, ═N—, —N═or —N(R3)—;
• wherein R3 is selected from hydrogen, (C1-C4)-straight or branched alkyl, (C3-C4)-straight or branched alkenyl or alkynyl, or (C1-C4) bridging alkyl, wherein said bridge is formed between the nitrogen atom to which said R3 is bound and any carbon atom of said alkyl, alkenyl or alkynyl to form a ring, and wherein said ring is optionally benzofused;
• wherein E is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S;
• and wherein no more than 4 ring atoms are selected from N, O or S;
• wherein 1 to 4 hydrogen atoms in E are optionally and independently substituted with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O—[(C1-C6)-straight or branched alkyl], O—[(C3-C6)-straight or branched alkenyl], (CH2)n—N(R4)(R5), (CH2)n—NH(R4)—(CH2)n-Z, (CH2)n—N(R4—(CH2)n-Z)(R5—(CH2)n-Z), (CH2)n-Z, O—(CH2)n-Z, (CH2)n—O-Z, S—(CH2)n-Z, CH═CH-Z, 1,2-methylenedioxy, C(O)OH, C(O)O—[(C1-C6)-straight or branched alkyl], C(O)O—(CH2)n-Z or C(O)—N(R4)(R5);
• wherein each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, O or S;
• wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z;
• each n is independently 0 to 4;
• each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, O or S;
• and wherein no more than 4 ring atoms are selected from N, O or S;
• wherein 1 to 4 hydrogen atoms in Z are optionally and independently substituted with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, O-(C1-C3)-straight or branched alkyl, C(O)O—[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or N—[(C1-C3)-straight or branched alkyl]2;
• wherein 1 to 4 hydrogen atoms in the bicyclic ring of formula (I) or formula (II) are optionally and independently substituted with Q;
• wherein Q is selected from E, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E;
• wherein Q is optionally substituted with up to 3 substituents selected from halogen, OH, O-(C1-C6)-alkyl, O—(CH2)n-Z, NO2, CO2H, C(O)—O—(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)n-Z;
• and
• wherein the ethylene groups adjacent to the nitrogen atom in the bicyclic rings of formula (I) and formula (II) are optionally be benzo fused.