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US 6,660,737 B2Granted
Medicinal uses of hydrazones
AssigneeThe Procter & Gamble Company
InventorsJi-In Kim Almstead, Nicholas John Izzo, David Robert Jones, Richard Masaru Kawamoto
Life of this patent
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Abstract
Compounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.
Claims5
A method of increasing vascularization of tissue in a mammalian subject in need of such treatment comprising administering to said subject a safe and effective amount of a compound having the structure:
- wherein
- (a) R1 is selected from the group consisting of aryl, cycloalkyl, heteroaryl, and heterocycloalkyl;
- (b) R2 is hydrogen when Z is a single covalent bond or nil when Z is a double covalent bond,
- (c) R3 is selected from the group consisting of hydrogen and lower alkyl;
- (d) R4 is hydrogen when Z is a single covalent bond or nil when Z is a double covalent bond;
- (e) R5 is selected from the group consisting of hydrogen and lower alkyl;
- (f) R6 is selected from the group consisting of aryl, cycloalkyl, heteroaryl, and heterocycloalkyl;
- or an optical isomer, diastereomer or enantiomer, or pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.
5 more elements
Dependencies are inferred from the claim text.