Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists

A compound selected from the group consisting of a compound of the formula

• wherein A is selected from the group consisting of saturated and unsaturated bivalent alkylene of up to 9 carbon atoms and bivalent cycloalkylene of 3 to 7 carbon atoms, both unsubstituted or substituted with at least one member of the group consisting of halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, heteroaryl of 5 to 14 carbon atoms, heteroarylalkyl of 5 to 14 hetero carbon atoms and 1 to 6 alkyl carbon atoms, cycloalkyl of 3 to 12 carbon atoms, oxo and cycloalkylalkyl of 3 to 12 cycloalkyl carbon atoms and 1 to 6 alkyl carbon atoms, B is selected from the group consisting of hydrogen, —NH—CO—OR5—NH—SO2—R5, —NH—SO-Aryl of 6 to 14 carbon atoms, —NH—SO2-heteroaryl of 5 to 14 carbon atoms, —NH—CO—R5, —NO—CO-Aryl of 6 to 14 carbon atoms, —NH—CO-heteroaryl of 5 to 14 carbon atoms, —NH—CO—NH—R5, —NH—CO—NH-aryl of 6 to 14 carbon atoms, —NH—CO—NH-heteroaryl of 5 to 14 carbon atoms, —NH—SO2—NH—R5, —NH—SO2—NH-aryl of 6 to 14 carbon atoms and —NH—SO2—NH-heteroaryl of 5 to 14 carbon atoms, D is selected from the group consisting of hydrogen, aryl of 6 to 14 carbon atoms, heteroaryl of 5 to 14 carbon atoms and R5, R1 and R2 are individually hydrogen or unsubstituted or substituted alkyl of 1 to 6 carbon atoms with the substituents being at least one R3, R3 is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, halogen, —CF3, —OH, —NO2 and —NH2, R4 is selected from the group consisting of hydrogen, Alk-COO-Alk′ and alkyl of 1 to 6 carbon atoms unsubstituted or substituted with a member selected from the group consisting of —OH, alkoxy of 1 to 4 carbon atoms, alkyl SO2— of 1 to 4 carbon atoms,
• Alk is alkyl of 1 to 6 carbon atoms, Alk′ is alkyl of 1 to 4 carbon atoms, R7, R7a and R7b are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 14 carbon atoms and aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, Q— is a pharmaceutically acceptable anion or R4 is selected from the group consisting of
• R5 is selected from the group consisting of alkyl of 1 to 14 carbon atoms unsubstituted or substituted with at least one halogen, cycloalkyl of 3 to 12 carbon atoms, cycloalkylalkyl of 3 to 12 cycloalkyl carbon atoms and 1 to 6 alkyl carbon atoms, aralkyl of 6 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms and heteroarylalkyl of 5 to 14 aryl carbon atoms and 1 to 6 alkyl carbon atoms, the aryl and heteroaryl being unsubstituted or substituted with at least one R3, R6 is selected from the group consisting of hydrogen, —OH, —NO2, alkyl-OCO— of 1 to 6 carbon atoms and alkyl-O—CO—O— of 1 to 6 carbon atoms in all stereoisomeric forms and mixtures thereof and its non-toxic, pharmaceutically acceptable addition salts with a base or acid.