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US 6,660,717 B1Granted
Folliculogenesis
AssigneeAkzo Nobel N.V.
InventorsUrsula Maria Rose, Marcel van Duin
Life of this patent
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Abstract
The present invention relates to the use of GDF-9 in assisted reproduction and to kits comprising GDF-9. A method is provided to stimulate follicle and oocyte development and maturation. The method comprises administering GDF-9 in combination with gonadotropins.
Claims9
A follicular growth stimulating composition, comprising:
- an effective amount of Growth Differential Factor-9 (GDF-9) to stimulate follicle growth and oocyte development and maturation,
- an effective amount of at least one gonadotropin and
- a pharmaceutically acceptable carrier.
A method for stimulating follicle and oocyte development and maturation, comprising:
- administering to a female patient in need thereof an effective amount of Growth Differential Factor-9 (GDF-9) and an effective amount of at least one gonadotropin to stimulate follicle and oocyte development and maturation.
A follicle and oocyte development and maturation kit, comprising:
- a plurality of package units comprising a mixture of at least one gonadotropin and Growth Differential Factor-9 (GDF-9).
A follicle and oocyte development and maturation kit, comprising:
- at least one gonadotropin and Growth Differential Factor-9 (GDF-9) in separate package units.
A method of assisted reproduction, comprising:
- administering to a female patient an effective amount of Growth Differential Factor-9 (GDF-9) and an effective amount of at least one gonadotropin to stimulate growth of follicles.
Dependencies are inferred from the claim text.