Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
AssigneeMassachusetts Institute of Technology
InventorAlexander M. Klibanov
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Abstract
Methods and formulations for delivery of macromolecules, such as proteins, polysaccharides, and nucleic acids, are disclosed, where the macromolecule is dissolved or dispersed in a low toxicity organic solvent which can be aerosolized for delivery to a patient's lungs by inhalation. Optionally, appropriate solubility enhancers are also present in the formulations composition.
Claims11
A formulation for pulmonary delivery of a bioactive agent comprising
- a solution or suspension of a bioactive agent to be delivered in a biocompatible organic solvent suitable for aerosolization of the bioactive molecule, wherein the solvent is a class 3 residual solvent.
A method of delivery of a bioactive agent comprising administering to a patient an aerosol formulation of a solution or suspension of the bioactive agent in a biocompatible organic solvent, wherein the solvent is a class 3 residual.
Dependencies are inferred from the claim text.