Modular assembly for reagentless affinity separation and detection of analyte

A modular assembly for affinity separation of an analyte from a sample comprising:

• an affinity support comprised of a metal;
• and
• at least one sensor unit comprising:
• an affinity module, said affinity module having a binding affinity for said analyte;
• and
• a signal-competent reporter module, said signal competent reporter module being directly or indirectly signal-responsive to complex formation between said affinity module and said analyte, wherein said signal competent reporter molecule is immobilized on said affinity support, and said signal-competent reporter module being spaced from said affinity support such that said complex formation provides a change in the distance between said signal-competent reporter module and said affinity support.