Heteroaryl substituted benzothiazole dioxetanes
AssigneePE Corporation
InventorsBrooks Edwards, Irena Bronstein, Zhixian Wang
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Abstract
Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: The heteroaryl substituent Y can be, for example, a pyridyl group or a benzothiazolyl group. The heteroaryl substituted benzothiazole compounds are substantially stable at room temperature. Kits including the heteroaryl substituted dioxetane compounds as well as methods for using these compounds for detecting the presence of one or more analytes in a sample are also provided.
Claims29
A 1,2-dioxetane compound capable of producing light energy when decomposed, represented by the formula:
- wherein R may independently be any branched alkyl or cycloalkyl group which provides stabilization for the dioxetane or wherein both R groups together form a cycloalkyl or polycycloalkyl moiety Spiro bound to the dioxetane ring;
- wherein each R group or the Spiro bound moiety may be unsubstituted or substituted with one or more electron-withdrawing groups or electron-donating groups;
- wherein R1 is an aryl group or an alkyl group of 1-20 carbon atoms which may be optionally substituted with 1 or more halogen atoms;
- wherein Y is a heteroaryl group;
- and wherein X is a protecting group which can be removed by non-enzymatic chemical or enzymatic means.
Dependencies are inferred from the claim text.