Epidermis/dermis equivalents and aged skin equivalents shaped therefrom
AssigneeSociete L'Oreal S.A.
InventorsHervé Pageon, Daniel Asselineau, Pierre Tachon
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Abstract
An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen. An aged dermis equivalent, the epidermis equivalent obtained and methods of producing the aged skin and/or aged dermis equivalent and/or the epidermis equivalent.
Claims49
Aged skin equivalent, comprising at least one epidermis equivalent and one aged dermis equivalent wherein the aged dermis equivalent comprises at least glycated collagen and fibroblasts and wherein the epidermis equivalent comprises at least keratinocytes, said epidermis equivalent having a modified distribution of expression of β1 integrin.
A method for preparing an aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, the method comprising
- (1) preparing an aged dermis equivalent comprising a lattice of at least glycated collagen fibroblasts;
- and
- (2) reconstructing an epidermis equivalent comprising at least keratinocytes onto the lattice of step 1;
- wherein the epidermis equivalent has a modified distribution of β1 integrin expression.
Dependencies are inferred from the claim text.