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US 6,660,505 B2Granted
Isolation of carboxylic acids from fermentation broth
AssigneeCognis Corporation
InventorMichael D. Staley
Life of this patent
Estimating the term…
Abstract
A process for recovering carboxylic acids from an aqueous mixture such as a fermentation broth using a solvent containing at least one olefin without the need for first removing the spent microorganism cells is provided. A co-solvent which increases the partition coefficient of the solvent relative to the carboxylic acid may optionally be included.
Claims54
A method for isolating carboxylic acid from an aqueous mixture comprising:
- providing an aqueous mixture containing at least one carboxylic acid;
- contacting the aqueous mixture with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent
- adjusting the pH of the aqueous mixture to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the aqueous mixture.
3 more elements
A method for isolating carboxylic add from an aqueous mixture comprising:
- providing an aqueous mixture containing at least one carboxylic acid;
- contacting the aqueous mixture with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the aqueous mixture's pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the aqueous mixture,
- wherein the carboxylic acid is selected from the group consisting of oxalic acid, maleic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, phthalic acid, azelaic acid, sebacic acid, dodecanedioic acid, brassylic acid, 9-octadecenedioic acid, C-36 dimer acid, caprylic acid, pelargonic acid, capric acid, undecylic acid, lauric acid, myristic acid pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic add, arachidic acid, palmitoleic acid, oleic acid, erucic acid, linoleic acid, linolenic acid and isomers thereof.
4 more elements
A method for isolating carboxylic acid from an aqueous mixture comprising:
- providing an aqueous mixture containing at least one carboxylic add;
- contacting the aqueous mixture with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the aqueous mixture's pH to from about 1.5 to about 6.0;
- adjusting the viscosity of the aqueous mixture by heating to a temperature from about 70° C. to about 80° C.;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the aqueous mixture.
4 more elements
A method for isolating carboxylic acid from an aqueous mixture comprising:
- providing an aqueous mixture containing at least one carboxylic acid;
- contacting the aqueous mixture with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the aqueous mixture's pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the aqueous mixture,
- wherein the carboxylic acid-separating medium contains a minor amount by weight thereof of cosolvent selected from the group consisting of tertiary-butyl acetate, methyl isobutyl ketone, methyl tert-butyl ether, 2-octanol, 1-octanol, dodecanol, decanol, 2-octanone, 2-decanone and combinations thereof.
4 more elements
A method for isolating carboxylic add from an aqueous mixture comprising:
- providing an aqueous mixture containing a microorganism and at least one carboxylic add;
- contacting the aqueous mixture with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent
- adjusting the aqueous mixtures pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the aqueous mixture.
3 more elements
A method for isolating carboxylic acid from a fermentation broth comprising:
- providing a fermentation broth containing a microorganism and at least one carboxylic acid;
- contacting the fermentation broth with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the fermentation broth's pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the fermentation broth.
3 more elements
A method for isolating carboxylic acid from a fermentation broth comprising:
- providing a fermentation broth containing at least one carboxylic acid;
- contacting the fermentation broth with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the fermentation broth's pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the fermentation broth,
- wherein the carboxylic acid-separating medium contains a minor amount by weight thereof of cosolvent selected from the group consisting of tertiary-butyl acetate, methyl isobutyl ketone, methyl tert-butyl ether, 2-octanol, 1-octanol, dodecanol, decanol, 2-octanone, 2-decanone and combinations thereof.
4 more elements
A method for isolating carboxylic add from a fermentation broth comprising:
- providing a fermentation broth containing at least one carboxylic acid;
- contacting the fermentation broth with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the fermentation broth's pH to from about 1.5 to about 6.0;
- adjusting the viscosity of the fermentation broth by heating to a temperature from about 70° C. to about 80° C.;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the fermentation broth.
4 more elements
A method for isolating carboxylic acid from a fermentation broth comprising;
- providing a fermentation broth containing at least one carboxylic acid;
- contacting the fermentation broth with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent;
- adjusting the pH of the fermentation broth to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the fermentation broth.
3 more elements
A method for isolating carboxylic acid from a fermentation broth comprising:
- providing a fermentation broth containing at least one carboxylic acid;
- contacting the fermentation broth with a carboxylic acid-separating medium the major amount up to the entire amount by weight of which is made up of olefin solvent
- adjusting the fermentation broth's pH to from about 1.5 to about 6.0;
- allowing the carboxylic acid to separate into the carboxylic acid-separating medium;
- and,
- isolating the carboxylic acid-separating medium containing the carboxylic acid from the fermentation broth,
- wherein the carboxylic acid is selected from the group consisting of oxalic avid, maleic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, phthalic acid, azelaic acid, sebacic acid, dodecanedioic acid, brassylic acid, 9-octadecenedioic acid, C-36 dimer acid, caprylic acid, pelargonic acid, capric acid, undecylic acid, lauric acid, myristic acid pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic acid, arachidic acid, palmitoleic acid, oleic acid, erucic acid, linoleic acid, linolenic acid and isomers thereof.
4 more elements
Dependencies are inferred from the claim text.