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AssigneeBio-Rad Laboratories, Inc.
InventorsSteven R. Binder, Jodi L. Goodrich, Zara Safarian
Estimating the term…
Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.
A method for verifying that an analytical test sample to be analyzed for the presence or absence of a biological condition is a sample of human serum and does not contain human plasma, said method comprising analyzing said sample to detect the presence therein of the a subunit of human Factor XIII protein, any a subunit thus detected being an indication of the presence of human plasma in said sample.
Dependencies are inferred from the claim text.