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US 6,660,484 B2Granted
Colorimetric glycopolythiophene biosensors
AssigneeThe Regents of the University of California
InventorsDeborah J. Charych, Myung-Gi Baek
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Abstract
The present invention relates to methods and compositions for the direct detection of analytes using observable spectral changes in biopolymeric systems. In particular, the present invention allows for the direct colorimetric detection of analytes using color changes that occur in glycopolythiophene polymer systems in response to selective binding of analytes.
Claims17
A biopolymeric composition comprising:
- a plurality of polymer molecules,
- a plurality of spacer molecules, and
- one or more ligands,
- wherein said plurality of polymer molecules are selected from the group consisting of polythiophene, and glycopolythiophene, and wherein said plurality of spacer molecules join said plurality of polymer molecules to said one or more ligands, and wherein said biopolymeric composition undergoes a color change upon the binding of an analyte to said one or more ligands.
1 more element
A method of detecting the presence of an analyte, comprising:
- a) providing:
- i) a plurality of polymer molecules, wherein said plurality of polymer molecules are selected from the group consisting of polythiophene, and glycopolythiophene;
- ii) a plurality of spacer molecules;
- iii) one or more ligands;
- and
- iv) a sample suspected of containing an analyte;
- b) contacting said plurality of biopolymeric molecules with said sample;
- and
- c) detecting a color change in said plurality of biopolymeric molecules caused by the binding of said analyte to said one or more ligands.
6 more elements
Dependencies are inferred from the claim text.