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US 6,660,483 B1Granted
Diagnostic marker for neurological conditions
AssigneeAGY Therapeutics, Inc.
InventorsKalev Kask, Thorsten Melcher, Daniel J. Chin
Life of this patent
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Abstract
The invention relates to a human phospholipase C expressed in the brain (B-PLC) and induced in response to ischemic brain tissue. The inventions provides methods and reagents useful for diagnosis and treatment of hypoxic-ischemic brain insult such as stroke.
Claims6
A method for the diagnosis of a neurological condition in an animal, comprising
- (a) obtaining a biological sample from the animal;
- and
- (b) detecting an increased level of B-PLC comprising the polypeptide of SEQ ID NO:7 in the sample compared to the level in a healthy animal,
- wherein said increased level is diagnostic of a neurological condition in the animal.
1 more element
A method for the diagnosis of a neurological condition in an animal, comprising
- (a) obtaining a biological sample from the animal;
- and
- (b) detecting an increased level of B-PLC in the sample compared to the level in a healthy animal by using an antibody that specifically binds the polypeptide of SEQ ID NO:7,
- wherein said increased level is diagnostic of a neurological condition in the animal.
1 more element
Dependencies are inferred from the claim text.