Sandwich assays for collagen type I fragments
AssigneeOsteometer Biotech A/S
InventorsChristian Rosenquist, Per Qvist
Life of this patent
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Abstract
Sandwich assays for collagen degradation products are conducted using an antibody of the same specificity on both sides of the sandwich or using a first antibody reactive with an epitope contained in the sequence EKAHDGGR and a second antibody which may be the same or different.
Claims10
A method of measurement of the rate of type I collagen resorption comprising measuring in a sample the amount of a population of collagen fragments by a sandwich assay using a first antibody reactive with a first epitope located in the collagen amino acid sequence EKAHDGGR (SEQ. ID NO:1) or in isomerised and/or racemised variants thereof and a second antibody reactive with a second epitope, wherein the first and second epitopes are located in the same fragment.
A method of measurement of the rate of type I collagen resorption comprising measuring in a sample the amount of a population of collagen fragments by a sandwich assay using a first antibody reactive with a first epitope located in a first occurrence of the collagen amino acid sequence EKAHDGGR (SEQ. ID NO:
- 1) or in isomerised and/or racemised variants thereof and a second antibody reactive with a second epitope located in second occurrence of the amino acid sepuence EKAHDGGR (SEQ. ID NO:
- 1) or in isomerised and/or racemised variants thereof, wherein the first and ssecond epitooes are located in the same fragment.
Dependencies are inferred from the claim text.