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US 6,660,466 B1Granted
Di-nitrogen heterocycle compositions
AssigneeIsis Pharmaceuticals, Inc.
InventorsPhillip Dan Cook, Pei-Pei Kung, Andrew Mamoru Kawasaki
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Abstract
Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
Claims8
A method of preparing a library of chemical compounds comprising:
- providing a scaffold comprising at least one reactive functionality thereon;
- contacting said scaffold with a mixture comprising at least four appendage moieties to form covalent bonds between said at least four appendage moieties and said at least one reactive functionality, thereby forming an intermediate library;
- and contacting said intermediate library with a reducing agent under conditions effective to reduce said covalently bound appendage moeities, thereby forming said library of chemical compounds.
Dependencies are inferred from the claim text.