Process for manufacturing coated granules with masked taste and immediate release of the active principle
AssigneeEthypharm
InventorsNoureddine Nouri, Jean-Marc Zuccarelli, Charles Chauveau, Etienne Bruna
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Abstract
The invention concerns a method for making coated granules with masked taste and instant release of the active principle which consists in: first, mixing the constituents of a powder comprising at least the active principle and a granular disintegrating agent; then, granulating the resulting powder, in the presence of a mixture of carriers comprising at least a binding agent capable of binding the particles together to obtain grains; coating the grains formed by spraying a suspension comprising at least a coating agent and a membrane disintegrating agent; finally drying the resulting coated granules.
Claims25
A process for manufacturing coated granules with masked taste, and immediate release of the active principle, according to which:
- the constituents of a powder comprising at least the active principle and a granular disintegrant are first dry-mixed;
- the powder obtained is then granulated, in the presence of a mixture of excipients comprising at least one binder for binding the particles together to give grains;
- the grains formed are then coated by spraying with a suspension comprising at least one coating agent and a membrane disintegrant;
- finally, the coated granules obtained are dried.
A process for manufacturing coated granules with masked taste, and immediate release of the active principle, according to which:
- the constituents of a powder comprising at least the active principle and a granular disintegrant are first dry-mixed;
- the powder obtained is then granulated, and the grains formed are then coated, in the presence of the same mixture of excipients comprising at least one binder for binding particles together to give grains;
- at least one coating agent and a membrane disintegrant;
- the rate of spraying of the mixture of excipients being higher during the granulation step than during the coating step, and the atomization pressure of the mixture of excipients being lower during the granulation step than during the coating step;
- finally, the coated granules obtained are dried.
Dependencies are inferred from the claim text.