Injectable microspheres for dermal augmentation and tissue bulking
AssigneeBiosphere Medical, Inc.
InventorsJean-Marie Vogel, Richard Thomas, Egisto Boschetti
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Abstract
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.
Claims53
A method for dermal augmentation in a mammal comprising injecting a composition of elastic, hydrophilic, non-toxic and substantially spherical microspheres in a biocompatible carrier to said mammal through a needle of about 30 guage or smaller;
- wherein the microspheres comprise an acrylic polymer and a positive charge.
A kit for performing dermal augmentation comprising:
- (a) a 30 guage or smaller needle;
- (b) means for injecting a liquid based composition through said needle;
- and
- spherical (c) biocompatible, elastic, hydrophilic, non-toxic and substantially spherical microspheres injectable through said needle and are not capable of being eliminated by macrophage or other elements of said mammal's immune system after injection thereof, wherein the microspheres comprise an acrylic polymer and a positive charge.
A method of tissue bulking in a mammal comprising injecting a composition of elastic, hydrophilic, non-toxic and substantially spherical microspheres in a biocompatible carrier to said mammal through a needle of about 18 to about 26 gauge;
- wherein the microspheres comprise an acrylic polymer and a positive charge.
A kit for performing tissue bulking comprising:
- (a) an 18 to 26 gauge needle;
- (b) means for injecting a liquid based composition through said needle;
- and
- (c) biocompatible, elastic, hydrophilic, non-toxic and substantially spherical microspheres injectable through said needle and are not capable of being digested or eliminated by macrophage or other elements of said mammal's immune or lymphatic system after injection thereof, wherein the microspheres comprise an acrylic polymer and a positive charge.
Dependencies are inferred from the claim text.