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US 6,660,296 B2Granted
Sustained-release microgranules containing diltiazem as active principle
AssigneeLaboratories des Produits Ethiques Ethypharim
InventorsPatrice Debregeas, Gérard Leduc, Pascal Oury, Pascal Suplie
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Abstract
Novel forms of sustained-release microgranules (LP) containing diltiazem are disclosed. The microgranules consist of a neutral granular carrier coated with an active layer including diltiazem or a pharmaceutically acceptable salt thereof as the active principle, a surfactant and a binder, and an outer layer providing sustained release of the active principle (layer LP).
Claims29
A composition comprising:
- (1) sustained-released (SR) microgranules containing Diltiazem which are free from water-soluble organic acid, comprising:
- a neutral granular support coated with an active layer comprising:
- Diltiazem or a pharmaceutically acceptable salt thereof as active principle,
- a surfactant, and
- a binder,
- and a layer which ensures slow release of the active principle (SR layer), comprises a single coating agent ensuring sustained release, and
- (2) sustained-released microgranules containing Ditiazem which are free from water-soluble organic acid, comprising:
- a neutral granular support coated with an active layer comprising,
- Diltiazem or a pharmaceutically acceptable salt thereof as active principle,
- a surfactant, and
- a binder,
- and a layer which ensures rapid release of the active principle (SR layer), and comprises a single coating agent ensuring sustained release.
9 more elements
Dependencies are inferred from the claim text.