Emulsion vehicle for poorly soluble drugs
AssigneeSonus Pharmaceuticals, Inc.
InventorsKarel J. Lambert, Panayiotis P. Constantinides, Alexander K. Tustian, Steven C. Quay
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Abstract
An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.
Claims22
A composition, comprising:
- one or more tocopherols or derivatives thereof;
- a co-solvent;
- a tocopherol polyethylene glycol succinate;
- an aqueous phase;
- and
- a chemotherapeutic agent, wherein the chemotherapeutic agent is at least one of a taxoid, a taxine, a microtubule-binding agent, or a taxane;
- wherein the composition is substantially free of any monohydric alcohol, wherein the composition is an emulsion or a microemulsion having an oil and a water phase, and wherein all of the chemotherapeutic agent is in the oil phase.
A pharmaceutical composition, consisting essentially of:
- paclitaxel,
- one or more tocopherols or derivatives thereof,
- a tocopherol polyethylene glycol derivative,
- polyethylene glycol,
- a polyoxypropylene-polyoxyethylene glycol nonionic block polymer, and an aqueous phase.
Dependencies are inferred from the claim text.